Morpheus: The anthropomorphic personification of dreams, a powerful individual assisted in his duties by a helm made from the bones of a dead God, and Matthew, a raven that was once a man. Morpheus battles to defend his realm the Dreaming from the invading demon Nightmare, but with his helmet in the hands of his opponent, can even he hope to succeed?

Nightmare: A demon that lives in a nightmare world and feeds on mortal fears. Nightmare, armed with Morpheus' helm hopes to conquer the Dreaming oblivious to both the distorted reality their battle has created and his role as pawn in a far greater game.

Blackheart: The son of Mephisto, critical of his father's methods but seemingly destined to take after him as a trickster and manipulator of mortals. Blackheart hopes to use Ghost Rider as a tool to unleash the powers contained in Hellboy's Right Hand of Doom.

Abe Sapien: A mysterious amphibian, who, like Hellboy is an agent of the Bureau for Paranormal Research and Defence. Dispatched with Hellboy to investigate the Ghost Rider sightings, Abe joins with Wolf and Kody, in attempt to subdue Hellboy, before it's too late.

Dan Ketch: Blaze's brother, possessed by a Spirit of Vengeance and becoming Ghost Rider whenever innocent blood is spilled. Death enlists Ketch as a valuable ally.